• PositionAssociate Professor
  • EMailwirotetunti@yahoo.com


Education

  •     2001        Medicinal Chemistry, College of Pharmacy, Universty of Texas at Austin    USA
  •     1994        Biochemistry, Faculty of Medicine, Chiang Mai University    Thailand
  •     1988        Faculty of Pharmaceutical Sciences, Chulalongkorn University    Thailand


Professional Experience

  •     2002    Lecturer
  •     2004    Assistant Professor
  •     2014    Associate Professor


Research Interests

  •     1.    Anticancer drugs based on telomerase inhibition


Publications

  •     2001    Tuntiwechapikul W, Lee JT, Salazar M. Design and synthesis of the G-quadruplex-specific cleaving reagent Perylene-EDTA-Iron(II). J Am Chem Soc. 2001; 123: 5606-7.
  •     2001    Tuntiwechapikul W, Salazar M. Cleavage of telomeric G-quadruplex DNA with Perylene-EDTA-Fe(II). Biochemistry 2001; 40: 13652-8.
  •     2002    Tuntiwechapikul W, Salazar M. Mechanism of in-vitro expansion of long DNA repeats: effect of temperature, repeat length, and DNA polymerases. Biochemistry 2002; 41: 854-60.
  •     2002    Tuntiwechapikul W, David WM, Kumar D, Kerwin SM, Salazar M. DNA modification by 4-Aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity. Biochemistry 2002; 41: 5283-90.
  •     2002    Tuntiwechapikul W. Telomerase as a target for anticancer agents. Chiang Mai Med Bull. 2002; 41: 223-31.
  •     2004    Pham T, Lai D, Ji D, Tuntiwechapikul W, Friedman JM, Lee TR. Well-ordered self-assembled monolayer surfaces can be used to enhance the growth of protein crystals. Colloid Surface B 2004; 34: 191-6.
  •     2006    Tuntiwechapikul W, Taka T, Bethencourt M, Makonkawkeyoon L, Randall Lee T. The influence of pH on the G-quadruplex binding selectivity of perylene derivatives. Bioorg Med Chem Lett. 2006; 16: 4120-6.
  •     2008    Lee TC, Chen PC, Lai TY, Tuntiwechapikul W, Kim JH, Lee TR. Aliphatic dithiocarboxylic acids: New adsorbates for soft lithographic patterning. Applied Surface Science 2008; 254: 7064-8
  •     2009    Makonkawkeyoon L, Pharephan S, Tuntiwechapikul W, Makonkawkeyoon S. Application of Monoclonal and Polyclonal Antibodies to Hb Barts for the Detection of Thalassemias. The Open Hematology Journal 2009; 3, 11-7.
  •     2009    Pradupsri P, Loetchutinat C, Nuntasaen N, Meepowpan P, Tuntiwechapikul W, Pompimon P. Anticancer activities of styrylpyrone from the leaves and twigs of Goniothalamus maewongensis via cell cycle arrest. American Journal of Applied sciences 2009; 6, 2018-2
  •     2010    Makonkawkeyoon L, Pharephan S, Sirivatanapa P, Tuntiwechapikul W, Makonkawkeyoon S. Development of an ELISA strip for the detection of {alpha} thalassemias. Haematologica. 2010; 95, 338-9.
  •     2010    Tuntiwechapikul W, Taka T, Songsomboon C, Kaewtunjai N, Imsumran A, Makonkawkeyoon L, Pompimon W, Lee TR. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J Med Food. 2010; 13,1347-54.
  •     2012    Taka T, Joonlasak K, Huang L, Lee TR, Tam-Chang SW, Tuntiwechapikul W. Down-regulation of the human VEGF gene expression by perylene monoimide derivatives. Bioorg Med Chem Lett. 2012; 22, 518-22.
  •     2012    Nayyatip S, Thaichana P, Buayairaksa M, Tuntiwechapikul W, Meepowpan P, Nuntasaen N, Pompimon W. Aristolactam-type alkaloids from Orophea enterocarpa and their cytotoxicities. Int J Mol Sci. 2012; 13, 5010-8.
  •     2013    Taka T, Huang L, Wongnoppavich A, Tam-Chang SW, Lee TR, Tuntiwechapikul W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorg Med Chem. 2013; 21, 883-90. (IF 2011 = 2.921)
  •     2014    Taka T, Changtam C, Thaichana P, Kaewtunjai N, Suksamrarn A, Lee TR, Tuntiwechapikul W. Curcuminoid derivatives enhance telomerase activity in an in vitro TRAP assay. Bioorg Med Chem Lett. 2014; 24: 5242-6.
  •     2015    Pharephan S, Intorasoot S, Tuntiwechapikul W, Makonkawkeyoon S, Makonkaw-keyoon L. Cloning and expression of a recombinant single-chain variable fragment antibody specific to Hemoglobin Bart€™s. Asian Pac J Health Sci. 2015; 2: 28-35


Books

  •     1.    2013 ͳ٪Է: õչ չ ISBN: 978-616-335-671-0


Training Fellowships

  •     2002.    Postdoctoral training, Department of Chemistry, University of Houston, Texas, USA


Research Grants

  •     2002    Investigation of perylene derivatives with different charges and their telomerase inhibitory effect    Faculty of Medicine Research Fund    Principal Investigator    199,900 baht
  •     2003    Investigation of G-quadruplex-mediated telomerase inhibitors with selective cytotoxicity    Thailand Research Fund    Principal Investigator    480,000 baht
  •     2007    Studies of perylene derivatives and plant chemicals that Iihibit telomerase for anticancer therapy    Thailand Research Fund    Principal Investigator    1,200,000 baht
  •     2007    Finding telomerase inhibitors from medicinal plants to use as cancer chemotherapeutic agents    National Research Council of Thailand    Principal Investigator    1,000,000 baht
  •     2008    Production of telomerase by transient expression of gene-containing plasmids for direct telomerase inhibition assay    Faculty of Medicine Research Fund    Principal Investigator    200,000 baht
  •     2009    Structural determination of anti-telomerase agents to use as cancer-specific chemotherapeutic agents    National Research Council of Thailand    Principal Investigator    632,500 baht
  •     2009    Inhibition of vascular endothelial growth factor gene expression by perylene derivatives    Faculty of Medicine Research Fund    Principal Investigator    200,000 baht
  •     2010    Effects of perylene derivatives on telomere shortening and senescence in lung cancer cells    Faculty of Medicine Research Fund    Principal Investigator    200,000 baht
  •     2011    Activation of telomerase activity by curcuminoid derivatives    Faculty of Medicine Research Fund    Principal Investigator    200,000 baht