Difficulty breathing in a 3-month-old infant (Page 1/2)
Prepared by...
Virat Sirisanthana, M.D.
Department of Pediatrics, Chiang Mai University
Chief Complaint: Difficulty breathing
History of Present Illness
A 3-month-old girl had a 1-week history of progressive difficulty in breathing. Her mother reports that her child has turned "dark" while sucking breast milk for the last three days. Today although she is restless, there has been no reduction in oral intake. The mother is not aware of any fever.
Past Medical History
The patient was born at Maternal-child hospital in Chiang Mai. Her birth weight was 3000 kg. Her mother had history of positive VDRL at the first trimester, which was treated with penicillin injection.
The patient's birth history was uneventful. After birth she has been well until this admission.
Immunization History
She received the routine vaccinations (BCG at birth, DPT and OPV at 2 -month-old).
Family History
She is the only child. The patient’s parents are healthy.
Physical Examination
The patient is in moderate respiratory distress. BW 5 kg.
Vital Signs
Temperature:37.8 C   Pulse: 158 beats per minute  Respiration: 72 per minute  
Blood Pressure 75/40  mmHg
HEENT
No evidence of rhinitis, otitis, or conjunctivitis.  Oropharynx appears normal.
Chest
Moderate intercostal retractions, no wheeze. Air exchange is fair.
Cardiovascular
Good perfusion. Normal heart sounds without murmur
Abdomen
Liver  5 cm below RCM. Spleen 3 cm below LCM.
Genitourinary System
Normal
Extremities
Moderate cyanosis, no clubbing
Skin
Normal
Nervous System
Normal
Laboratory
  Blood gas (room air) : hypoxia (O2 saturation =59%) with normocapnia
Chest radiograph: (see below).
   
   
Figure 1 shows radiographs taken at the time of admission. The radiograph demonstrates bilaterally increased interstitial markings Complete blood count: Hemoglobin: 10 g/dl,  hematocrit: 34 % , platelets: 88,500
WBC: 12,400  Differential: 40 % polys, 54 % lymphocytes, 5 % monocytes, 1% eosinophils,
RBC morphology: normochromic normocytic
   
Serology : HIV-Ab : positive
Serum Enzymes: Lactate dehydrogenase: 709 units/L
  Blood culture : sent
 
Questions
1.Which of the following is the most likely diagnosis?
A. Opportunistic pneumonia, particularly Pneumocystis carinii or cytomegalovirus (CMV)
B. Pneumococcal pneumonia
C. Asthmatic exacerbation s
D. Foreign body aspiration
E. Viral respiratory infection
2.Which of the following is the SECOND most likely diagnosis?
A. Opportunistic pneumonia, particularly Pneumocystis carinii or cytomegalovirus (CMV)
B. Pneumococcal pneumonia
C. Asthmatic exacerbation
D. Foreign body aspiration
E. Viral respiratory infection
 
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